研究業績

原著論文

• "Asymmetric Synthesis of Pentasubstituted Cyclohexanes through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction"
  A. S. Odoh, L. Aidanpää, N. Umekubo, H. Matoba, N. Mori, Y. Hayashi
  Eur. J. Org. Chem., 2021, 6670-6673
• "Synthesis of bicyclo[2.2.2]octanes with a quaternary bridgehead carbon by diphenylprolinol silyl ether mediated domino reaction"
  N. Umekubo, T. Taniguchi, K. Monde, Y. Hayashi
  Asian. J. Org. Chem., 2021, 10, 3261-3265
• "Enantiodivergent one-pot synthesis of axially chiral biaryls using organocatalyst-mediated enantioselective domino reaction and central-to-axial chirality conversion"
  S. Koshino, T. Taniguchi, K. Monde, E. Kwon, Y. Hayashi
  Chem. Eur. J. , 2021, 27, 15786-15794
• "Halogen Bonding of N-Halosuccinimides with Amines and Effects of Brønsted Acids in Quinuclidine-Catalyzed Halocyclizations"
  J. Li, E. Kwon, M. J. Lear, Y. Hayashi
  Helv. Chim. Acta, 2021, 104, e210080
• "Asymmetric synthesis of functionalized 9-methyldecalins using a diphenylprolinol silyl ether-mediated domino Michael/Aldol reaction"
  Y. Hayashi, H. A. Salazar, S. Koshino
  Org. Lett., 2021, 23, 6654-6658
• "Direct Cyclopropanation of -Cyano -Aryl Alkanes by Light Mediated Single Electron Transfer between Donor-Acceptor Pairs"
  J. Li, M. J. Lear, Y. Hayashi
  Chem. Eur. J. , 2021, 27, 5901-5905
• "Oxidative Peptide Bond Formation of Glycine-Amino Acid using 2-(Aminomethyl)malononitrile as a Glycine Unit"
  X. Wang, J. Li, Y. Hayashi
  Chem. Commun. , 2021, 57, 4283-4286
• "Time and Pot Economy in Total Synthesis"
  Y. Hayashi
  Acc. Chem. Res., 2021, 54, 1385-1398
• "Time Economy in Total Synthesis"
  Y. Hayashi
  J. Org. Chem. , 2021, 86, 1-23
• "Evidence for an enolate mechanism in the asymmetric Michael reaction of -unsaturated aldehydes and ketones via a hybrid system of two secondary amine catalysts"
  N. Umekubo, T. Terunuma, E. Kwon, Y. Hayashi
  Chem. Sci. , 11, 11293-11297
• "Asymmetric Synthesis of Corey Lactone and Latanoprost"
  N. Umekubo, Y. Hayashi
  Eur. J. Org. Chem., 6221-6227
• "Highly Enantioselective Access to syn-α, γ-Dihydroxycarbonyl Building Blocks via Organocatalyst-Mediated Aldol Reaction as a Key Step"
  Y. Hayashi, X. Wang, G. Kawauchi
  Chem. Lett., 49, 940-943
• "One-pot synthesis of chiral cis-hydrindanes via diphenylprolinol silyl ether mediated domino reaction and aldol condensation"
  N. Umekubo, R. Iwata, *Y. Hayashi
  Chem. Lett., 49, 867-869
• "Asymmetric Michael reaction of aldehydes and α-cyano α, β-unsaturated esters catalyzed by diphenylprolinol silyl ether; a facile asymmetric route to 3,4,5-trisubstituted piperidines"
  Y. Hayashi, A. S. Odoh, N. Kranidiotis-Hisatomi
  ChemCatChem., 12, 2412-2415
• "Inversion of the Axial Information during Oxidative Aromatization in the Synthesis of Axially Chiral Biaryls with Organocatalysis as a Key Step"
  S. Koshino, A. Takikawa, K. Ishida, T. Taniguchi, K. Monde, E. Kwon, S. Umemiya, Y. Hayashi
  Chem. Eur. J., 26, 4525-4530
• "Pot and time economies in the total synthesis of Corey lactone"
  N. Umekubo, Y. Suga, *Y. Hayashi
  Chem. Sci., 11, 1205-1209
• "Pot-Economical Total Synthesis of Clinprost"
  Umekubo, N.; *Hayashi, Y.
  Org. Lett., 22, 9365-9370
• "Asymmetric Domino Reaction of-Unsaturated Aldehydes and -Acyl -Unsaturated Cyclic Ketones Catalyzed by Diphenylprolinol Silyl Ether"
  *Hayashi, Y.; Suga, Y.; Umekubo, N.
  Org. Lett., 22, 8603-8607
• "Evidence for an enolate mechanism in the asymmetric Michael reaction of -unsaturated aldehydes and ketones via a hybrid system of two secondary amine catalysts"
  Umekubo, N.; Terunuma, T.; Kwon, E.; *Hayashi, Y.
  Chem. Sci. , 11, 11293-11297
• "214. Asymmetric Synthesis of Corey Lactone and Latanoprost"
  Umekubo, N.; *Hayashi, Y.
  Eur. J. Org. Chem., 6221-6227
• "Asymmetric One-Pot Mukaiyama Michael/Michael reaction catalyzed by diphenylprolinol silyl ether"
  Umekubo, N.; Hayashi, Y.
  Eur. J. Org. Chem., 5596-5600
• "Highly Enantioselective Access to syn-α, γ-Dihydroxycarbonyl Building Blocks via Organocatalyst-Mediated Aldol Reaction as a Key Step"
  *Hayashi, Y.; Wang, X.; Kawauchi, G.
  Chem. Lett., 49, 940-943
• "One-pot synthesis of chiral cis-hydrindanes via diphenylprolinol silyl ether mediated domino reaction and aldol condensation"
  Umekubo, N.; Iwata, R.; Hayashi, Y.
  Chem. Lett., 49, 867-869
• "Asymmetric Michael reaction of aldehydes and α-cyano α, β-unsaturated esters catalyzed by diphenylprolinol silyl ether; a facile asymmetric route to 3,4,5-trisubstituted piperidines"
  *Hayashi, Y.; Odoh, A. S.; Kranidiotis-Hisatomi, N.
  ChemCatChem, 12, 2412-2415
• "Inversion of the Axial Information during Oxidative Aromatization in the Synthesis of Axially Chiral Biaryls with Organocatalysis as a Key Step"
  Koshino, S.; Takikawa, A.; Ishida, K.; Taniguchi, T.; Monde, K.; Kwon, E.; Umemiya, S.; *Hayashi, Y.
  Chem. Eur. J., 26, 4525-4530
• "Pot and time economies in the total synthesis of Corey lactone"
  Umekubo, N.; Suga, Y., *Hayashi, Y.
  Chem. Sci., 11, 1205-1209
• "Pot and time economies in the total synthesis of Corey lactone,"
  Umekubo, N.;Suga, Y.; Hayashi, Y.
  Chem. Sci., 2019年12月23日, 11, 1205-1209
• "Asymmetric Synthesis of Biaryl Atropisomers Using an Organocatalyst-Mediated Domino Reaction as the Key Step"
  Hayashi, Y.;Takikawa, A.;Koshino, S.;Ishida, K.
  Chem. Eur. J., 2019年6月19日, 21, 10319-10322
• "Asymmetirc Michael Reaction of -CF3 Thioester and -Unsaturated Aldehyde Catalyzed by Diphenylprolinol Silyl Ether"
  Hayashi, Y.;Yamda, T.; Sato, M.;Watanabe, S.;Kwon, E.;Iwasaki, K.;Umemiya, S.
  Org. Lett. , 2019年6月18日, 21, 5183-5186
• "Asymmetric Synthesis of Chiral 1,3-Dimethyl Units Through a Double Michael Reaction of Nitromethane and Crotonaldehyde Catalyzed by Diphenylprolinol Silyl ether"
  *Hayashi, Y; Toda, S.
  Synlett, 2019年1月, 30, 442-448
• "Asymmetrci Michael Reaction of Aldehydes and Dicyanoalkenes Catalyzed by Diphenylprolinol Silyl Ether"
  *Hayashi, Y.; Kranidiotis-Hisatomi, N.; Sakamoto, D.; Oritani, K.; Kawamoto, T.; Kamimura, A.
  Eur. J. Org. Chem., 2018年11月6日, 6843-6847
• "Domino Michael/Michael Reaction for the Formation of Chiral Spirocycles Using a Diphenylprolinol Silyl Ether"
  *Hayshi, Y.; Nagai, K.; Umemiya, S.
  Eur. J. Org. Chem., 2018年9月20日, 678-681
• "Asymmetric Michael reaction of aldehyde and -substituted -nitroacrylate catalyzed by diphenylprolinol silyl ether"
  Sakamoto, D.; *Hayashi, Y.
  Chem. Lett., 2018年7月, 47(7), 833-835

総説・解説

• 「有機触媒を用いたビアリール型軸不斉化合物の新規合成法の開発」 林　雄二郎, 化学工業, 38-47, 9, 2019年9月1日